May 1-2nd, an audience of 275 doctors, researchers, pharmacists, advanced-practice providers and medical trainees gathered to hear from 48 speakers in shared recognition of the importance of working to mitigate serious complications in immunocompromised individuals. The international event included participants from over one hundred institutions, thirteen countries, and six continents. The symposium addressed COVID-19, Cytomegalovirus and Human Herpesvirus-6, Fungal Disease, Immunotherapy, Respiratory Virus Disease, Antimicrobial Resistance and Microbiome, and Vaccines. Speakers also discussed case presentation and round table discussions with audience participation within these subject areas. Seventy-one trainees were able to attend the symposium as a part of the travel stiped program.
Introduction
Co-chairs: Michael Boeckh, Catherine Liu, Joshua Schiffer
Fred Hutch Cancer Center, University of Washington
Keynote Address
Introduction: Michael Boeckh, Fred Hutch Cancer Center, University of Washington
COVID-19 Vaccines in Immunocompromised Patients
Lindsey Baden, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard University
COVID-19
Chairs: Catherine Liu, Fred Hutch Cancer Center, University of Washington
Helen Chu, University of Washington
COVID-19 in Immunocompromised Hosts: Outcomes and Therapeutic Management Strategies
Ghady Haidar, University of Pittsburgh
Case Presentation and Round Table Discussion (with audience response system): Challenges in Management of COVID-19 in Immunocompromised Hosts— Protracted Infection and Persistent Viral Shedding
Discussants:
Catherine Liu, Fred Hutch Cancer Center, University of Washington
Helen Chu, University of Washington
Ghady Haidar, University of Pittsburgh
Madeleine Heldman, Duke University
Mini Kamboj, Memorial Sloan Kettering
Cytomegalovirus and Human Herpesvirus-6 — New Approaches
Chairs: Ajit Limaye, University of Washington
Danniel Zamora, Fred Hutch Cancer Center, University of Washington
CMV After Hematopoietic Cell Transplantation: New Drugs and Immune Monitoring
Roy Chemaly, MD Anderson Cancer Center
CMV in Solid Organ Transplant Recipients: New Drugs and Immune Monitoring
Joanna Schaenman, University of California Los Angeles
HHV-6 Pulmonary Disease: What is the Evidence?
Joshua Hill, Fred Hutch Cancer Center, University of Washington
Case Presentation and Round Table Discussion (with audience response system): A Challenging Case of Resistant CMV Infection
Case Presenter: Danniel Zamora, Fred Hutch Cancer Center, University of Washington
Discussants:
Joshua Hill, Fred Hutch Cancer Center, University of Washington
Genovefa Papanicolaou, Memorial Sloan Kettering Cancer Center
Michael Boeckh, Fred Hutch Cancer Center, University of Washington
Roy Chemaly, MD Anderson Cancer Center
Danniel Zamora, Fred Hutch Cancer Center, University of Washington
Ajit Limaye, University of Washington
Fungal Disease
Chairs: Monica Slavin, MacCallum Cancer Centre, Melbourne, Australia
Ricardo La Hoz, UT Southwestern Medical Center
New Antifungal Agents
Dimitrios Kontoyiannis, MD Anderson Cancer Center
Case Presentation and Round Table Discussion (with audience response system): Controversies in Fungal Management (Mucor Therapy, Threshold for Proceeding to Transplantation)
Discussants:
David Fredricks, Fred Hutch Cancer Center, University of Washington
Monica Slavin, MacCallum Cancer Centre, Melbourne, Australia
Dimitrios Kontoyiannis, MD Anderson Cancer Center
Julian Lindsay, Fred Hutch Cancer Center
Ricardo La Hoz, UT Southwestern Medical Center
Immunotherapy
Chairs: Joshua Hill, Fred Hutch Cancer Center, University of Washington
Madeleine Heldman, Duke University
Best Trainee Abstract
Infections in CAR T-Cell Recipients
Muhammad Bilal Abid, Medical College of Wisconsin
Advances in Virus-Specific Immunotherapy
Genovefa Papanicolaou, Memorial Sloan Kettering Cancer Center
Keynote Address
Introduction: Per Ljungman, Karolinska Institutet, Stockholm, Sweden
Respiratory Virus Vaccinations in Immunocompromised Hosts
Janet Englund, Seattle Children's Hospital, University of Washington
Respiratory Virus Disease
Chairs: Angela Campbell, Centers for Disease Control and Prevention
Per Ljungman, Karolinska Institutet, Stockholm, Sweden
Impact of Respiratory Viruses in Hematopoietic Cell Transplantation and Hematology/Oncology Patients During COVID-19 and Beyond
Alpana Waghmare, Seattle Children's Hospital, University of Washington, Fred Hutch Cancer Center
Impact of Respiratory Viruses in Solid Organ Transplant Patients During COVID-19 and Beyond
Lara Danziger-Isakov, Cincinnati Children’s Hospital Medical Center
Case Presentation and Round Table Discussion (with audience response system): To Delay or Not Delay Transplantation
Discussants:
Alpana Waghmare, Seattle Children's Hospital, University of Washington, Fred Hutch Cancer Center
Per Ljungman, Karolinska Institutet, Stockholm, Sweden
Angela Campbell, Centers for Disease Control and Prevention
Cynthia Fisher, University of Washington
Lara Danziger-Isakov, Cincinnati Children’s Hospital Medical Center
Michael Ison, National Institute of Allergy and Infectious Diseases
Antiviral Treatment (Including COVID-19)
Michael Ison, National Institute of Allergy and Infectious Diseases
Monoclonal Antibodies (Including COVID-19)
Jim Boonyaratanakornkit, Fred Hutch Cancer Center, University of Washington
Keynote Address
Introduction: David Fredricks, Fred Hutch Cancer Center, University of Washington
Advances in Fecal Microbiota Transplantation for the Eradication of Multidrug-Resistant Organisms and Treatment of Graft-Versus-Host Disease
Julian Marchesi, Imperial College London, England
Antimicrobial Resistance and Microbiome
Chairs: David Fredricks, Fred Hutch Cancer Center, University of Washington
Stephanie Pouch, Emory University
Challenges and Opportunities for Management of Antimicrobial Resistance in the Immunocompromised Host
Judith Anesi, University of Pennsylvania
Phage Therapy for Multidrug-Resistant Organisms
Saima Aslam, University of California San Diego
Vaccines
Chairs: Sanjeet Dadwal, City of Hope
Upton D. Allen, University of Toronto, The Hospital for Sick Children
Progress in Herpesvirus Vaccines: Varicella-Zoster Virus and Cytomegalovirus
Mark Schleiss, University of Minnesota
How to Approach Hesitant Patients on Vaccination
Annika Hofstetter, Seattle Children’s Hospital, University of Washington
Vaccination: Special Considerations in Immunocompromised Hosts
Steve Pergam, Fred Hutch Cancer Center, University of Washington
Closing | Co-chairs: Michael Boeckh, Catherine Liu, Joshua Schiffer
Fred Hutch Cancer Center, University of Washington
