Collaborating to Advance Your Science
Our expert staff are responsive to your needs and committed to collaboration in service of your science. Here’s how we do it.
Before a new project begins, our team works with you to devise an experimental strategy and project plan. Based on your scope of work, we draft a customized quote, detailing each service we would provide. Once we reach final agreement on scope of work, timeline and cost, both parties sign a service agreement detailing each party’s responsibilities during the lifetime of the project.
We ensure that all regulatory pathways and infrastructure are in place before beginning work with mice or accepting tissue samples. Throughout the life of the project, we provide regular progress updates and immediately communicate any emergent problems.
Interested in learning more? We’re here to answer your questions about our services and to learn about your research goals and possible scope of work.
Case Studies
Our services in patient-derived xenograft, or PDX, models and genetically engineered mouse models, or GEMMs, have helped to propel discovery in research on a range of cancers and other diseases. These case studies illustrate our impact.
PDX Models of Bladder Cancer
The lab of Dr. Andrew Hsieh at Fred Hutch worked with our PDX team to investigate whether mRNA translation represents a therapeutic vulnerability in bladder cancer.
GEMMs of Poison Exon Loss
Our GEMM team worked with Dr. Robert Bradley of Fred Hutch to create technically challenging, first-of-a-kind mouse models for studying the role of poison exons in organismal viability.
GEMMs to Study IgG in Breast Milk
The GEMM team created a precise knockout mouse model to allow Dr. Meghan Koch at Fred Hutch to study how a particular breast milk antibody isotype shapes infant health.
Example Projects
Below are examples of typical projects with the Preclinical Modeling core’s PDX and GEMM teams that demonstrate how we work with investigators.