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Mapping tumor cell heterogeneity in castrate-resistant prostate cancer
From the Haffner Lab, Human Biology and Clinical Research Divisions
RNA stability may play a role in prostate cancer
New research links mutations in RNA region that helps regulate protein production to progression and drug resistance
Hit the “reset” button on acquired drug resistance of cancer cells
From the Bradley Lab, Public Health Sciences and Basic Sciences Divisions and collaborating Abdel-Wahab Lab, Memorial Sloan Kettering Cancer Center
Seeking targeted treatments for pancreatic cancer
American Cancer Society fellowship to Dr. Nithya Kartha supports search for vulnerabilities in most aggressive pancreatic tumor subtype
New insights into drug resistance in small cell lung cancer
Scientists discover a single gene’s outsized role in drug resistance — and use its vulnerability to re-sensitize tumors to chemotherapy in preclinical models
Taking the shortcut to frontline treatment
From Dr. Schmitt and the Radich lab, Clinical Research Division
Targeted therapies push metastatic prostate cancer in new directions
Combination therapy could help stave off new “escape variant” of disease that arises in response to powerful treatments
Good News: First extensive immune profiling of sarcomas shows some types may be susceptible to immunotherapy
Celebrating faculty and staff achievements
Super drugs for superbugs: Creative ways to combat antibiotic resistance
New discoveries could overcome antibiotic development stalemate, stay ahead of bacteria’s steady march toward drug resistance
Researchers uncover how poxviruses such as smallpox evolve rapidly - despite low mutation rates
Study reveals novel ‘accordion-like’ means of viral adaptation against host viral defenses
Three-drug H. pylori therapy better for some than four
New results from large Latin American SWOG study contradict clinical trial findings in Europe and Asia; geographic variations in antibiotic resistance may validate different drug regimens for different populations
NCI awards $11.5 million to Fred Hutchinson Cancer Research Center to lead breast cancer research consortium
Projects include developing targeted therapies to treat drug-resistant tumors