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Rewriting the story about the molecules that turn genes on and off
Fred Hutch researchers discover that most transcription factors in budding yeast don’t follow the textbook example of binding close to the genes they regulate
New Science Spotlight Articles
Every month, Fred Hutch postdoc writer/editors summarize two papers from each of our scientific divisions to stimulate collaborations across campus
April 16, 2025
Sleepy cells rely on Sir2 to remodel their DNA landscape
From the Tsukiyama Lab, Basic Sciences Division
Evolutionary cell biologist Dr. Grant King named a Hanna Gray Fellow
Long fascinated by life seen and unseen, King awarded eight years of funding to finish postdoctoral training at Fred Hutch and establish an independent lab
In the race to replicate, it’s better to think small-scale
From The Bedalov Lab, Human Biology and Translational Science and Therapeutics Divisions
Acidic media favor entry of yeast into quiescence
From the Tsukiyama lab, Basic Sciences Division
500 replication origins in the yeast genome? Try 5000!
From the Bedalov Lab, Translational Science and Therapeutics and Human Biology Divisions
Actively inactive: the regulation of RNA during quiescence in yeast cells
From the Tsukiyama Lab, Basic Sciences Division
To Ψ or not to Ψ: how PUS1 knows where to pseudouridylate mRNAs
From the Stoddard lab, Basic Sciences Division
Grant King named a 2023 Damon Runyon Fellow
Malik Lab postdoc will study how cells handle extra-chromosomal DNA
Delineating transcriptional regulatory processes in yeast
From the Hahn Lab, Basic Sciences Division
Ssd1-2 RNA binding protein directs sporulation in response to stress
From the Breeden Lab, Basic Sciences Division
Rude Awakening: examining the cell’s rapid recovery from quiescence
From the Tsukiyama lab, Basic Sciences Division
Transcription factor binding: a sharp view of a fuzzy interaction
From the Hahn lab, Basic Sciences Division
Sharing is (not necessarily) caring: the evolution of cooperative behavior
From the Shou lab, Basic Sciences Division
SCAMPRing to get ahead: the enduring battle for supremacy between parasite and host
From the Malik Lab, Basic Sciences Division
Pulling it together: Uncovering a role for chTOG at the kinetochores
From the Biggins Lab, Basic Sciences Division
A ‘selfish gene’ that poisons its own host
Discovery of genes that divide two species in a simple fungus sheds light on complex evolutionary principles
How cells sense and respond to the outside world
Cells employ unexpected method to respond to environmental cues
How Dr. Barry Stoddard's science fueled promising therapy for glioblastoma — the disease that killed his mom
How Dr. Barry Stoddard's lab work helped create an experimental drug for glioblastoma — the same disease that killed his mother
‘Every day something new’: Dr. Sue Biggins selected as HHMI investigator
Flexible support from the prestigious nonprofit will open new research doors