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Rewriting the story about the molecules that turn genes on and off
Fred Hutch researchers discover that most transcription factors in budding yeast don’t follow the textbook example of binding close to the genes they regulate
New Science Spotlight Articles
Every month, Fred Hutch postdoc writer/editors summarize two papers from each of our scientific divisions to stimulate collaborations across campus
April 16, 2025
New methods reveal cancer mechanism in ancient genes
Fred Hutch researchers discover that overproduction of DNA packaging material predicts aggressive brain and breast tumors, which could lead to cheaper diagnostic tests and new drug therapies
Switching sides: How MLL-rearranged leukemias leverage oncoproteins to evade treatment
From the Henikoff Lab, Basic Sciences Division
Histone mark profiling identifies KLF7 as critical for CAR-T cell proliferation
From the Henikoff lab, Translational Science and Therapeutics and Basic Sciences Divisions
New techniques, collaborations push patient-focused precision oncology forward
$5.4M NCI award supports Dr. Chris Kemp’s multi-disciplinary discovery platform for cancer-therapy targets
New technique could help make precision medicine more widely available
Simple CUT&Tag adaptation gives information about genetic regulatory elements in formalin-fixed tumor samples
An old drug gets a new look: DNA damaging agent aclarubicin found to disrupt chromatin and stimulate RNA Pol II elongation
From the Henikoff Lab, Basic Sciences Division and Cancer Basic Biology Program of the Cancer Consortium
MulTI-Tag: your ticket to profiling chromatin
From the Henikoff Lab, Cancer Basic Biology Program, Cancer Consortium.
License to Kill: Latency HIV-CRISPR pinpoints how to blow latent HIV’s cover
From the Emerman and Henikoff Labs, Pathogen Associated Malignancies and Cancer Basic Biology Programs, Cancer Consortium.
Peeling back the layers of a cell’s epigenomic data
From the Henikoff and Setty labs, Basic Sciences and Public Health Sciences Divisions
Drs. Harmit Malik and Steve Henikoff elected to American Academy of Arts and Sciences
Election honors scientists’ contributions to understanding of fundamental biology
Hopes and predictions for 2022
Hutch researchers look ahead to an increase in cancer screening, improved vaccines and greater trust in science
Epigenetic heterogeneity helps cancer cells change their minds
From the Henikoff Lab, Basic Sciences Division and the Meshinchi Lab, Clinical Research Division
You’ve got something in your eye: cellular reprogramming in development and cancer
From the Henikoff Lab, Basic Sciences Division
Omics made easier
To see the big picture, just add ‘ome’
Fundamental proteins that guide embryo development are co-opted by cancer
Researchers discover why some critical DNA-packaging proteins called histones evolve rapidly — and may give cancer a boost
Short H2A histones, part II: a natural-born oncogene lurking in our genomes
From the Malik, Henikoff, Bleakley, and Bradley labs, Basic Sciences Division