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Driver’s ed: watching HSV co-infection and recombination in vivo
From the Jerome Lab, Vaccine & Infectious Disease Division

Engineered HSV can trigger genetic chain reaction, rejigger HSV genes during co-infection
Proof-of-concept work raises hope that ‘gene drive’ could one day form basis of curative gene therapy for herpes

Herpes cure with gene editing makes progress in laboratory studies
Fred Hutch virologists eliminated at least 90% of HSV-1 in preclinical models of oral and genital herpes and reduced viral shedding in a study published in Nature Communications

Liver-humanized mice to study hepatis B virus infection
From the Jerome lab, Vaccine and Infectious Disease Division

Learning from the past to improve SARS-CoV-2 variant discovery
From Dr. Lue Ping Zhao and collaborating labs, Public Health Sciences, Clinical Research, and Vaccine and Infectious Disease Divisions

Researchers refine experimental gene therapy for herpes
Treatment sharply reduced viral shedding in laboratory mice

Discovering potential emerging SARS-CoV-2 variants
From the Zhao, Gilbert, Geraghty and Jerome labs, a collaboration between Public Health Sciences, Vaccine and Infectious Disease, and the Clinical Research Divisions

SARS-CoV-2 mutations associated with COVID-19 related hospitalizations
From the Quantitative Genetic Epidemiology Group, Jerome Lab, and Geraghty Lab. A collaboration between the Clinical Research, Public Health Sciences, and Vaccine and Infectious Disease Divisions.

Scientists predict progress against COVID-19, cancer in 2021
After a challenging and deadly 2020, some hopeful predictions for the new year

A year of research dominated by the coronavirus
Scientists applied diverse expertise to pandemic in 2020 while advancing discoveries and cures for cancer

Fearless Science is ...
Hutch researchers take bold approaches to solving hard problems

Suppressing immunity to fight HIV infection
From the Jerome lab, Vaccine and Infectious Disease Division

COVID-19 and what else? Researchers use metagenomics to find out
Pairing genome sequencing with cloud computing makes a speedy screen for coinfections, new viral threats

Timothy Ray Brown, who inspired millions living with HIV, dies of leukemia
For more than a decade after a stem cell transplant, he was the only person known to be cured of HIV/AIDS

Tip Sheet: Colorectal cancer, COVID-19 super-spreading, gene therapy for herpes, contagious cancer in Tasmanian devils – and more
Summaries of recent Fred Hutch research findings and other news with links for additional background and media contacts.

A cure for herpes? There is progress to report
Mouse studies show gene therapy can cause big drop in latent infections

New gene therapy approach eliminates at least 90% latent herpes simplex virus 1
In Nature Communications, Fred Hutch scientists demonstrate in a mouse model how gene therapy could cure an infection that afflicts billions of people