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From data to decisions: Enhancing CAR T-cell therapy with predictive modeling
From the Gauthier Group, Clinical Research Division

CAR T-cell therapy is the leading edge of care for post-transplant lymphoproliferative disorder
A Fred Hutch patient became the 17th in the world to receive this pioneering treatment

How does leukemia escape from immunotherapy?
Single-cell sequencing tech enables deep dive into mysterious results, sets stage for future improvements

Hopes and predictions for 2022
Hutch researchers look ahead to an increase in cancer screening, improved vaccines and greater trust in science

Fred Hutch at CROI: COVID-19 vaccine efficacy trials, T-cell immunity following vaccination, immune responses to SARS-CoV-2, and late-breaking science on HPV, HIV and long-term antiretroviral therapy
Conference on Retroviruses and Opportunistic Infections to be held virtually March 6 – 10, 2021

Advances in blood disorders research continue despite COVID-19
Expanding use of CAR T-cell therapies, gene editing lead to insights at virtual annual meeting of the American Society of Hematology

Tip Sheet: Colorectal cancer, COVID-19 super-spreading, gene therapy for herpes, contagious cancer in Tasmanian devils – and more
Summaries of recent Fred Hutch research findings and other news with links for additional background and media contacts.

Experimental, precision strategy targets unique cancer protein found in certain acute myeloid leukemia cases
Lab study shows promise of aiming genetically engineered T-cell therapy at a gene fusion

The New Yorker spotlights Fred Hutch’s pioneering cancer research
‘The Promise and Price of Cellular Therapies’ by Siddhartha Mukherjee traces journey from bone marrow transplantation to immunotherapy

Immunotherapy trailblazer Dr. Phil Greenberg to receive E. Donnall Thomas Lecture and Prize
American Society of Hematology honors his ‘vision, creativity and scientific rigor’ in T-cell therapy research

Immunotherapy prevents relapse in small leukemia trial
Engineered T cells kept leukemia from returning in 12 high-risk patients

Landmark scientific paper turns 40
First unequivocal proof in humans of immune cells’ cancer-curing power laid the groundwork for cancer immunotherapy, modern bone marrow transplantation

Forbes '30 Under 30' lists Hutch immunotherapy researcher Alex Salter
Grad student on short list of young health care influencers

5 questions with a cancer immunotherapy expert
Dr. Phil Greenberg to receive high honor for his contributions to the field

Revealing a new way that cancer can evade immunotherapy — and, maybe, how to stop it
How a new technology solved a mystery and honors one man’s legacy

Squelching ovarian cancer: the not-so-silent killer
The search continues for new biomarkers, better outcomes and, yes, cures for this deadly disease

Want to make better T-cell therapies? First, figure out how they work.
New study maps out activities, effects of widely used components in cellular immunotherapies

Nanoparticles open doors to cancer-fighting CAR T cells
Tiny liposome-based drug carriers make tumors more vulnerable to targeted immunotherapy